系统性红斑狼疮患者高尿酸血症与病情的关系

Correlation of Hyperuricaemia with Disease Severity in Patients with Systemic Lupus Erythematosus

目的:探讨高尿酸血症在系统性红斑狼疮(SLE)疾病发生发展中的作用.方法:收集94例临床确诊而且肾功能正常(或处于代偿状态)的SLE患者临床资料,分析其血清尿酸(SUA)水平及高尿酸血症发生情况与病情的关系.结果:SLE患者SUA水平及高尿酸血症发生率均显著高于年龄和性别匹配的正常人群;关节及皮肤受累不影响SLE患者SUA平均水平及高尿酸血症发生率,而肾脏受累的SLE患者SUA平均水平及高尿酸血症发生率显著高于未受累患者;直线相关分析发现:SUA水平与SLE患者年龄、病程、收缩压、舒张压和总胆固醇、血尿素氮和血清肌酐水平无相关关系;与血清甘油三酯水平呈正相关关系;与血清补体C3水平及血红蛋白量呈负相关关系,与系统性红斑狼疮疾病活动指数(SLEDAI)呈低度正相关关系.结论:高尿酸血症是SLE病程常见的一种代谢异常表现,并可能与SLE肾脏受累以及病情活动有关.

Objective:To investigate the role of hyperuricaemia in the development of systemic lupus erythematosus (SLE). Methods:Collecting the clinical data of 94 SLE patients who were clinically diagnosed and with normal renal function (or in a compensatory state), the correlation between the level of serum uric acid (SUA), incidence of hyper-uricaemia with disease severity was analyzed. Results:The level of SUA and the incidence of hyperuricaemia in SLE patients were both higher than the age and gender matched normal population. The level of SUA and incidence of hy-peruricaemia were not different between patients with or without arthritis and skin rash, but significantly higher in pa-tients with lupus nephritis when compared to those without lupus nephritis. Linear correlation analysis found that SUA level did not correlate with the age, duration of SLE, blood pressure, total cholesterol, blood urea nitrogen and creatinine level, but positively correlated with serum triglyceride level;negatively correlate with erythrocytopenia, se-rum complement C3 level and hemoglobin;low positively correlated with SLE disease activity index (SLEDAI). Con-clusion:Hyperuricaemia is a common metabolic disorder in the clinical course of SLE, and may correlate with renal involvement and disease activity in SLE patients.