妊娠期甲状腺抗体异常与不良妊娠结局的相关性研究

Study of the Correlation between Abnormal Thyroid Antibody and Adverse Pregnancy Outcomes during Gestation Period

目的:通过检测孕妇妊娠期甲状腺过氧化物酶抗体(thyroidperoxidase antibody,TPOAb),探讨妊娠期甲状腺抗体异常对不良妊娠结局的影响.方法:对2013-05~2014-04在内蒙古兴安盟人民医院产科门诊及入院孕妇行甲状腺功能检测,根据TPOAb抗体及甲功结果分组比较不良妊娠结局的关系.结果:入组1 296例孕妇,TPOAb阳性组甲功异常18例18.9%(18/95),TPOAb阳性甲状腺功能正常15例,18.9%(15/79),抗体阴性甲功正常105例,9.3%(105/1122).结论:妊娠期甲状腺过氧化物酶抗体异常与不良妊娠结局具有相关性.

Objective: By testing the thyroid peroxidase antibody(TPOAb)among pregnant woman, to investigate the influence of abnormal thyroid antibodies on adverse pregnancy outcome during gestation period. Methods:The thyroid functions of pregnant women in Obstetrical Department of Xing’an League People’s Hospital from May 2013 to April 2014 were tested. The pregnant women were grouped according to the result of TPOAb antibody and thyroid function, and the adverse pregnancy outcomes of each group were compared. Results:1296 patients were enrolled, 18 cases were positive TPOAb antibody with abnormal thyroid function, accounted for 18.9%(18/95);15 cases were positive TPOAb antibody with normal thyroid function, accounted for 18.9%(15/79); 105 cases were negative TPOAb antibody with normal thyroid function, accounted for 9.3%(105/1122). Conclusion:There is correlation be-tween TPOAb abnormality and adverse pregnancy outcome.