玉米赤霉烯酮所致氧化应激的研究进展

Research Progress on Oxidative Stress Induced by Zearalenone

玉米赤霉烯酮是一种真菌毒素,对动物具有生殖毒性、免疫毒性、细胞毒性、遗传毒性,并有促癌作用,还能引起机体的氧化应激。玉米赤霉烯酮广泛存在于饲料和谷物中,能引起动物慢性中毒、机能异常甚至死亡,对畜牧养殖业危害严重。介绍了玉米赤霉烯酮所致的氧化应激作用及其机制,以期为阐明该作用机制涉及的信号转导通路提供理论依据。

Zearalenone(ZEA) is a kind of mycotoxin with reproductive toxicity, immune toxicity, cytotoxicity and genotoxicity to animals as well as cancer promoting effects. In addition, it can also bring about oxidative stress as the body′s response. Because ZEA widely exists in feed and grains, it always causes animals′ chronic poisoning, dysfunction and even death, which poses a great threat to animal husbandry industry. The oxidative stress induced by zearalenone and its molecular mechanism are introduced in this paper, so as to provide theoretical basis for elucidating the signal transduction pathway involved in the mechanism.