3-氨基-5H-5-芳基吡唑[3,4-e]并-1,2,3,4-四嗪衍生物的合成

THE SYNTHESIS OF 3-AMINO-5H-5-ARYL PYRAZOLO[3,4-E][1,2,3,4]-TETRAZINE DERIVATIVES

目的:为了寻找干扰核酸代谢的抗肿瘤新药,设计和合成嘌呤生物碱的类似物3-氨基-5H-5-芳基吡唑[3,4-e]并-1,2,3,4-四嗪衍生物是有意义的。方法:以3,5-二氨基吡唑为原料,经过重氮化、偶合和分子内关环合成目标化合物3-氨基-5H-5-芳基吡哇[3,4-e]并-1,2,3,4-四嗪衍生物。结果:合成了六个新的嘌呤类似物。结论:通过IR、~1H-NMR、质谱和元素分析证实所得化合物为目标化合物。

Objective;To find the anti- tumor drugs of interference with nucleic acid metabolism,design and synthesize of analogues of purine alkaloids a series of novel 3- amino- 5- H- 5-aryl pyrazolo[3,4- e][1,2,3,4]- tetrazine derivatives are significant.Methods;Take 3,5- diamino- pyrazole as raw material via diazotization,coupling and intramolecular cyclization to synthesize the compounds 3- amino- 5- H- 5- arylpyrazolo[3,4- e][1,2,3,4]- tetrazine derivatives.Results Synthesized six new purine analogues.Conclusion;The structure of these compounds were confirmed by IR,'H-NMR,MS and elemental analysis.