自身抗体的检测在自身免疫性肝炎诊断中的应用

Application of Detection of Autoantibodies in Autoimmune Hepatitis Diagnosis

目的:探讨自身抗体检测在自身免疫性肝炎诊断中的应用。方法:采用EIA、IFA和(欧蒙)滴定平板等技术。结果:自身免疫性抗体检测对临床肝病学具有重要意义,检测结果能作为医师其它有效诊断方法和信息的辅助手段。抗SLA/LP抗体对AIH具有很高特异性且在病毒性肝炎中为阴性,虽然其在AIH中阳性率只有30%,但其阳性预测值将近100%,如果存在相应临床症状,每一个阳性结果基本上就可诊断为AIH。结论:虽然自身免疫性抗体检测是一种重要而有力新型检测工具,但在实践应用中应结合受检者的临床表现及其它诊疗程序进行综合分析和判断。

Objective:The purpose is that exploring and digging into detection of autoantibodies and clinical significance.Methods:The autoantibodies against SLA/LP and AMA and ASMA(and pANCA)that today be measured(EUROIMMUN) enzyme immunoassay(EIA)or Immunofluorescence assay(IFA),and so all.Results:The autoantibodies against SLA/LP that today probably have the heightest diagnostic accuracy of all antibodies involved in autoimmue hepatitis.And antibodies against SLA/LP can be considered to be cardinal antibodies for autoimmune hepatitis.Although their prevalence is only about 30%.The prediction value is about 100%.Conclusion:The determination of SLA/LP is a new and important component in the diagnostics of autoimmune disease of the liver.The prevalence of LKM-land SLA/LP was very low in Chinese patients with liver diseases.LKM-land SLA/LP was specific to AIH and it would be important to diagnosis of AIH.A definite clinical diagnosis should not be based on the result of the performed test only,but should be made by the physician after all clinical and laboratory findings have been evaluated.