期刊文献+

OPCML基因与卵巢癌研究进展

下载PDF
导出
摘要 卵巢癌是妇科常见的恶性肿瘤,也是妇科恶性肿瘤病人的首要死亡因素,死亡率高达70%,研究发现OPCML基因在其生长发展过程中也可能起重要作用。1 OPCML基因的结构与生物学功能OPCML基因即阿片肽结合蛋白基因(opioid-binding protein/cell adhesion molecule-like gene,OPCML)定位于人类染色体11q25,包含有7个外显子,全长有60kb,表达的蛋白位于细胞膜,是一个鸦片受体类的细胞黏附因子。
出处 《内蒙古医学杂志》 2010年第S5期55-56,共2页 Inner Mongolia Medical Journal
  • 相关文献

参考文献13

  • 1刘曼华,王莹,曹兴建,周峰,乔海风,鲁小燕,陶国华.OPCML基因甲基化发生率与上皮性卵巢癌发生发展的关系[J].中国癌症杂志,2008,18(12):950-952. 被引量:4
  • 2张松法,叶枫,陈怀增,吕卫国,谢幸.11q22-q25区候选抑癌基因OPCML、POU2F3、CUL-5启动子CpG岛甲基化与子宫颈癌的发生[J].实用肿瘤杂志,2006,21(5):440-442. 被引量:2
  • 3姚德生,李力,Kenneth Garson,Barbara C.Vanderhyden.重组慢病毒介导的OPCML基因的体外转导及其对卵巢上皮性癌细胞的抑制作用[J].中华妇产科杂志,2006,41(5):333-338. 被引量:4
  • 4Virpi Launonen,Frej Stenb?ck,Ulla Puistola,Risto Bloigu,Pia Huusko,Soili Kyt?l?,Antti Kauppila,Robert Winqvist.Chromosome 11q22.3-q25 LOH in Ovarian Cancer: Association with a More Aggressive Disease Course and Involved Subregions[J].Gynecologic Oncology.1998(2)
  • 5Marilee J. Wick,Guangsheng Fan,Horace H. Loh.Expression of OBCAM-related cDNA clones in Cos 1 cells: evidence for a phosphatidylinositol linkage to the cell membrane[J].Molecular Brain Research.1996(2)
  • 6M. Davis,A. Hitchcock,W.D. Foulkes.Refinement of two chromosome 11q regions of loss of heterozygosity in ovarian cancer[].Cancer Research.1996
  • 7Reed J,McNamee C,Rackstraw S,et al.Diglons are heterodimeric proteinscomposed of IgLON subunits,and Diglon-CO inhibits neurite outgrowth fromcerebellar granule cells[].Journal of Cell Science.2004
  • 8Robertson KD.DNA methylation and human disease[].Nature Reviews Genetics.2005
  • 9Sellar GC,Watt KP,Rabiasz GJ,et al.Opcml at 11q25 is epigenetically inactivated and has tumor suppressor function in epithelial ovarian cancer[].Nature Genetics.2003
  • 10Loh HH,Smith AP.Regulation of acute and chronic opioid receptor functions by OBCAM,a cell adhesion-like molecule[].NIDA Res Monogr.1996

二级参考文献25

  • 1张晶,叶枫,陈怀增,叶大风,吕卫国,谢幸.卵巢上皮性癌OPCML基因的表达缺失和启动子甲基化[J].中国医学科学院学报,2006,28(2):173-177. 被引量:2
  • 2姚德生,李力,Kenneth Garson,Barbara C.Vanderhyden.OPCML基因的克隆[J].广西医科大学学报,2006,23(2):220-222. 被引量:3
  • 3Long Wang,Jin-Shui Zhu,Ming-Quan Song,Guo-Qiang Chen,Jin-Lian Chen.Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray[J].World Journal of Gastroenterology,2006,12(43):6949-6954. 被引量:8
  • 4谭媛,姚德生,李力.OPCML抑制卵巢癌细胞的体外实验研究[J].广西医科大学学报,2007,24(2):266-269. 被引量:1
  • 5Launonen V,Stenback F,Puistola U,et al.Chromosome 11 q22.3-q25 LOH in ovarian cancer:association with a more aggressive disease course and involved subregions.Gynecol Oncol,1998,71:299 -304.
  • 6Gabra H,Watson JE,Taylor K J,et al.Definition and refinement of a region of loss of heterozygosity at 11 q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis.Cancer Res,1996,56:950-954.
  • 7Hanawa H,Kelly PF,Nathwani AC,et al.Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood.Mol Ther,2002,5:242-251.
  • 8Wang F,Li ZY,Chi ZQ,et al.Active opioid binding protein from rat brain:a glycoprotein containing alpha-methyl-D-mannoside residues.Zhongguo Yao Li Xue Bao,1989,10:481-484.
  • 9Wick MJ,Fan G,Loh HH.Expression of OBCAM-related cDNA clones in Cos 1 cells:evidence for a phosphatidylinositol linkage to the cell membrane.Brain Res Mol Brain Res,1996,36:322-328.
  • 10Loh HH,Smith AP.Regulation of acute and chronic opioid receptor functions by OBCAM,a cell adhesion-like molecule.NIDA Res Monogr,1996,161:141-153.

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部