新生儿高胆红素血症与心肌酶的关系

Relationship of Neonatal Hyper Bilirubinemia and Myocardial Enzymes

目的:研究新生儿高胆红素血症患儿心肌酶增高的临床意义。方法:选取2007年1月~2009年6月,我院收治的120例足月新生儿,高胆红素组60例,对照组(正常新生儿)60例,高胆红素组治疗前、后及对照组均行股静脉穿刺采血作肝功能、心肌酶谱(CK、CK-MB、LDH、AST)检测。结果:高胆红素组治疗前心肌酶谱与对照组比较明显升高,差异有统计学意义(P【0.01);高胆红素组治疗前后有显著性差异(P【0.01)。结论:新生儿高胆红素血症可发生心肌损害,早期心肌酶检测有助于发现其心肌损害,具有临床指导意义。

Objective:To analyze the clinical significance of myocardial enzymes in neonatal hyperbilirubinemia.Methods:120 cases of full-term newbones in the period from January 2007 to june 2009 at our hospitalwere determined.The hepatic function test,myocardial enzymes(CK,CK-MB,LDH,AST) were assayed in60 cases of neonatal hyperbilirubinemia both in prior-treatment and post-treatment,and in 30 cases ofhealthy newborns via femoral vein puncture.Results:The level ofmyocardial enzymes were obviously increased in the group ofhyperbilirubinemia compared with the group of healthy newborns(P<0.01) and were gradually tended to be normal level after treatment.The level of myocardial enzymes had significantdifference between priortreatment and post-treatment in neonatal hyperbiliru-binemia(P<0.01).Conclusion:Myocardial injury can occur in neonatal hyperbilirubinemia.The early detection of myocardial enzymes can be used as a valuablemonitoring index in clinical practice.