叉头框蛋白C2及胶质瘤相关癌基因同源蛋白-1表达与非小细胞肺癌相关性研究

Correlation Between Expression of Forkhead Box Protein C2, Glioma-associated Oncogene Homolog-1 and Non-small Cell Lung Cancer

目的探究叉头框蛋白C2(FOXC2)、胶质瘤相关癌基因同源蛋白-1(Gli-1)表达与非小细胞肺癌(NSCLC)相关性。方法选取2015年6月至2018年8月我院NSCLC患者79例作为研究对象,通过免疫组化法测定FOXC2、Gli-1,并分析其与NSCLC相关性。结果 NSCLC组织中FOXC2、Gli-1阳性表达率高于癌旁组织(P<0.05);Ⅰ期NSCLC组织中FOXC2、Gli-1阳性表达率低于Ⅱ～Ⅲ期(P<0.05);有淋巴结转移NSCLC组织中FOXC2、Gli-1阳性表达高于无淋巴结转移(P<0.05);FOXC2、Gli-1阳性表达与NSCLC呈正相关(r_1=0.431,r_2=0.404,均P<0.05)。结论 NSCLC组织中FOXC2、Gli-1阳性表达率较高,其异常表达与淋巴结转移、临床分期相关,有助于评估NSCLC转移能力及预后。

Objective To investigate the correlation between the expression of forkhead box protein C2(FOXC2)and glioma-associated oncogene homologous protein-1(Gli-1)and non-small cell lung cancer(NSCLC).Methods A total of 79 patients with NSCLC from June 2015 to August 2018 were enrolled in this study.FOXC2 and Gli-1 were determined by immunohistochemistry and their correlation with NSCLC was analyzed.Results The positive expression rate of FOXC2 and Gli-1 in NSCLC tissues was higher than that in adjacent tissues(P<0.05).The positive expression rate of FOXC2 and Gli-1 in stage I NSCLC tissues was lower than that in stage II^III(P<0.05).The positive expression of FOXC2 and Gli-1 in metastasis of NSCLC tissues was higher than that without lymph node metastasis(P<0.05).The positive expression of FOXC2 and Gli-1 was positively correlated with NSCLC(r1=0.431,r2=0.404,P<0.05).Conclusion The positive expression rate of FOXC2 and Gli-1 in NSCLC tissues is high.The abnormal expression is associated with lymph node metastasis and clinical stage,which is helpful to evaluate the metastatic ability and prognosis of NSCLC.