血管生长抑制剂TNP-470合并放射增敏治疗肿瘤的研究

Observation on the combinative effect of angiogenesis inhibitor TNP-470 and radiosensitizer in fractionized radiotherapy of a xenograft tumor model

目的 观察血管生长抑制剂TNP 470与放射增敏剂MISO在放疗中联合应用治疗肿瘤的效果。方法 以Lewis肺癌荷瘤小鼠模型比较TNP 470与增敏放疗联合的治疗方法与其他相应各对比治疗方法的差异。结果 TNP 470与放射增敏剂MISO在放疗中联合应用的治疗效果要明显好于其他治疗方法。结论 血管生长抑制剂TNP

Objective\ To examine the combinative anti\|tumor effect of angiogenesis inhibitor TNP\|470 and radiosensitizer MISO in radiotherapy. Methods\ A 6\|group in vivo experiment was conducted to evaluate the effects of TNP\|470 combining γ\|irradiation with or without MISO in the C57 mice bearing Lewis lung cancer. Results\ TNP\|470 combined with γ\|irradiation and MISO showed the best therapeutic effectiveness in vivo . Conclusion\ Angiogenesis inhibitor TNP\|470 could potentiate the efficacy of radiosensitizer in radiotherapy.\;