补肾活血通络法辅助治疗慢性再生障碍性贫血的临床研究

Clinical Study on Treatment of Chronic Aplastic Anemia Assisted by TCM for Reinforcing Shen and Activating Blood Circulation to Dredge Channels

目的 :观察补肾活血通络法辅助治疗慢性再生障碍性贫血 (CAA)的临床疗效 ,并探讨其作用机制。方法 :将 79例CAA患者随机分为治疗组和对照组。对照组单用西药治疗 ,治疗组用补肾活血通络方加西药治疗。观察临床疗效并分别于治疗前后采用酶联免疫吸附双抗体夹心 (ELISA)法检测血浆sFas、sFasL水平。结果 :两组的基本治愈率、总有效率分别为 37 5 0 %、87 5 0 %和 2 0 5 1%、6 1 5 4%。两组疗效比较差异有显著性 (P <0 0 1)。治疗前两组患者血浆sFas水平明显减低 ,治疗后治疗组sFas水平较治疗前明显升高 (P <0 0 5 ) ,与对照组比较差异有显著性 (P <0 0 1)。结论 :补肾活血通络法治疗CAA疗效好、毒副反应少。其作用机制可能是通过调节机体免疫功能 ,从而阻抑了CAA患者造血细胞的过度凋亡。

Objective:To observe the clinical efficacy of TCM for reinforcing Shen and activating blood circulation to dredge Channels in auxiliary treating chronic aplastic anemia (CAA), and to explore its mechanism. Methods:Seventy-nine patients with CAA were randomly divided into the treated group treated with TCM plus western medicine and the control group treated with western medicine alone. The clinical efficacy was observed and levels of plasma sFas and sFasL before and after treatment were determined by ELISA. Results:The basic cure rate and totoal effective rate in the treated group were 37.50% and 87.50%; while in the control group were 20.51% and 61.54% respectively. Comparison between the two groups showed significant difference (P<0.01). The sFas level was markedly lower in both groups before treatment, but after treatment, it got elevated in the treated group significantly (P<0.05), as compared with that in the control group, the difference was significant (P<0.01). Conclusion:TCM is effective in treating CAA with less toxic and side-effect, the mechanism might be the inhibition on over apoptosis of hematopoietic cells in CAA patients through regulating immune function of organism.