摘要
目的 探讨脑梗死时氧自由基浓度变化对血液流变学的影响。方法 测定 41例急性脑梗死 (ACI)患者和 30例健康人血浆丙二醛 (MDA)、氧化修饰低密度脂蛋白 (ox LDL)浓度及全血粘度 ( ηb) ,血浆粘度 ( ηp)、红细胞压积 (HCT)、血沉 (ESR)、纤维蛋白原 (FIB)、血小板粘附率 (FAD)等指标 ,进行统计学分析。结果 脑梗死组MDA、ox LDL及 ηb、ηp、HCT、ESR、FIB、FAD等指标均明显升高 ,与对照组比较均有显著性差异 (P <0 .0 1或P <0 .0 5 ) ;直线相关分析显示 :MDA与ox LDL、ηb( 2 0 0s-1)、ηb( 3s-1)、ηp及FAD呈显著正相关 (r1=0 .412 9,P <0 .0 1;r2 =0 .472 6 ,P <0 .0 1;r3=0 .5 0 12 ,P <0 .0 1;r4 =0 .316 7,P <0 .0 5 ;r5=0 .30 76 ,P <0 .0 5 )。结论 脑梗死急性期氧自由基的过度形成可引起血液粘度增高 ,其对血液粘度的影响是多途径的。
Objective To explore the relationship between oxygen free radical and hemorrheology in patients with cerebral infarction. Methods MDA-ox-LDL and ηb-ηp-HCT-ESR-FIB-FAD were measured in 41 cases with actue cerebral infarction, and were compared with those of 30 normal controls.Results The plasma MDA-ox-LDL and ηb-ηp-HCT-ESR-FIB-FAD in ACI group were significantly higher than those in the controls. The analysis of linear correlation show that MDA was positively correlated with ox-LDL-ηb(200s -1),ηb(3s -1)-ηp and FAD(r 1=0.4129,P<0.01;r 2=0.4726,P<0.01;r 3=0.5012,P<0.01;r 4=0.3167,P<0.05;r 5=0.3076,P<0.05).Conclusion The change of oxygen free radical may alter the hemorrheology of acute cerebral infarction patients, which influence hemorrheology in many ways.
出处
《中国血液流变学杂志》
CAS
2003年第2期126-127,129,共3页
Chinese Journal of Hemorheology
关键词
脑梗死
氧自由基
浓度变化
血液流变性
影响
oxygen free radical
malondialdehyde
hemorrheology
cerebral infarction