活血益气药不同剂量配伍对心梗后心衰大鼠心脏系数及功能的影响

Effect of Different Drug Dosage to Activate Blood Circulation and to Nourish Qi on Cardiac Function and Structure of Congestive Heart Failure Rats After Acute Myocardial Infarction

目的 :观察相同种类活血益气药的不同剂量配伍对心梗后心衰大鼠心脏系数、功能的影响。方法 :采用左冠脉结扎术致心梗后心衰大鼠模型 ,分别用活血益气方 (全方活血药量占全方 75 % )、益气活血方 (活血药量占全方2 5 % )、气血方 (活血药量占全方 5 0 % )于术后 4周给药至 8周 ,每日灌胃 ,以卡托普利作为阳性药。用阻抗法观察给药前后大鼠心脏功能、心脏系数的变化。结果 :心梗后心衰大鼠经 4周给药治疗后 ,心功能每搏输出量 (SV)、心输出量 (CO)、心脏指数 (CI)值都明显升高 (P <0 .0 1) ;同时 ,活血益气方 (活血药量占全方 75 % )、气血方 (活血药量占全方5 0 % )对模型动物治疗后心脏系数改善与假手术组相似 (P >0 .0 5 ) ,而益气活血方 (活血药量占全方 2 5 % )、卡托普利与假手术组比较 ,对其无改善 (P <0 .0 1)。结论 :活血益气药通过改善心梗后心衰模型大鼠心脏系数及功能 ,达到治疗心衰作用 ;同时 ,方剂配伍中多量活血药的应用 (活血药 /益气药为 75 %和 5 0 % )

Objective:To observe the effect of different drug dosage to activate blood circulation and to nourish Qi on cardiac function and structure of heart failure rats after acute myocardial infarction. Method: The congestive heart failure post cardiac infarction rats models subjected to left coronary occlusion were made and given different dosage of drug of Huoxue Yiqi and captopril (positive control)from 4 weeks to 8 weeks after operation.The cardiac function before and after using drugs were observed by impedance methods. Result:Treated by different dosage of drug of Huoxue Yiqi and captopil, cardiac function of heart failure rats after acute myocardial infarction improved,SV,CO,CI( P <0.01); at the same time, prescription of Huoxue Yiqi and Qixue could improve the model rats' heart coefficient,VS SHAM( P >0.05),but prescription of Yiqi Huoxue and captopril could not improve it. Conclusion: Drug to activate blood circulation and to increase qi can treat heart failure rats after acute myocardial infarction, through improving their function and structure. At the same time,more dosage of drug to activate blood circulation and to increase qi(Huoxue /Yiqi drug) may improve the model rats' heart coefficient.