芪冬颐心口服液对麻醉犬急性心肌梗死的保护作用

Protective Effect of Qi Dong Yi Xin on Acute Myocardial Infarction in Dogs

目的 :观察芪冬颐心口服液对犬急性心肌梗死的保护作用。方法 :采用麻醉开胸犬 ,结扎冠状动脉左前降支 (LAD) ,产生急性心肌梗死模型 ,测定犬冠脉循环和心肌氧代谢参数 ,心肌缺血程度 (∑ ST)和心肌缺血范围 (N ST) ,梗死面积及血清酶学变化。结果 :芪冬颐心口服液 1.0 ,2 .0g·kg-1可降低冠脉阻力 ,增加冠脉流量 ,减少心肌耗氧量 ,减轻心肌缺血程度和缺血范围 ,缩小心肌梗死面积 ,降低血清肌酸激酶 (CK)及乳酸脱氢酶 (LDH)活性。结论 :芪冬颐心口服液能减少心肌耗氧量 。

Objective: To observe the protective effects on acute myocardial infarction of QDYX in dog. Method: The corconary ciculation and cardial oxygen metabolism, the degree and range of myocardial ischemia,myocardial infarct size,and the changes of the enzymes in serum were determined by using the acute myocardial infarction model of ligation of LAD in the anaesthetized open chest dogs. Result: The coronary resistance and cardial oxygen consumption were decreased and the myocardial blood flow was increased in dogs treated with QDYX of 1.0,2.0 mg·kg -1 . The degree and range of myocardial ischemia,myocardial infarct size and the activity of serum CK, LDH were decreased in acute myocardial infarcion dogs treated with QDYX of 1.0,2.0 mg·kg -1 . Conclusion: QDYX can decrease cardial oxygen consumption in dogs, thus having protective effect on myocardial ischemia.