摘要
目的 :探讨银杏叶提取物对肾毒血清性肾炎 (Masugi肾炎 )血小板活化因子 (PAF)水平的影响及其可能的肾功能保护作用。方法 :制作大鼠肾毒血清性肾炎模型 ,随机分为模型组、治疗组及正常对照组。采用银杏叶提取物治疗肾炎大鼠 ,观察治疗前后大鼠尿中 PAF的变化及治疗后血清及肾组织 PAF和血肌酐的变化 ,同时观察银杏叶提取物对该模型动物肾脏病理变化的干预作用。结果 :与模型组相比 ,银杏叶提取物治疗组大鼠 2 4 h尿 PAF水平及尿蛋白降低 (P<0 .0 5 ) ;肾组织中 PAF含量减少以皮质为明显 (P<0 .0 5 ) ;同时肾功能(P<0 .0 1 )和肾病理改变也得到明显改善。结论 :银杏叶提取物可抑制肾毒血清性肾炎大鼠中 PAF水平 。
Objective: To investigate the effect of ginkgo biloba extract on platelet activating factor(PAF) and the protection on renal function in rat with nephrotoxic serum glomerulonephritis(as Masugi glomerulonephritis). Methods: The rat model of Masugi glomerulonephritis was induced by Vasslli's methods. Twentyfour animals were randomly divided into the model group, treatment group and nontreated control group. The rats were treated with ginkgo biloba extract. PAF and proteinuria in urine were measured before and after treatment. PAF in serum, renal cortex and renal medulla as well as serum creatinine were also measured after treatment. The effect of ginkgo biloba extract on the renal histopathology in this model was observed. Results: Compared to the model group, ginkgo biloba extract could significantly decrease proteinuria and PAF in urine of 24 hours ( P <0 05), serum( P <0 05), the renal cortex ( P <0 05) and renal medulla, especially in the renal cortex.Prominent histopathological changes and improvement of renal function ( P <0 01) were observed in treatment group. Conclusion:Ginkgo biloba extract can inhibit PAF level and has beneficial effects on Masugi glomerulonephritis.
出处
《中国中西医结合急救杂志》
CAS
2003年第3期146-148,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
云南省自然科学基金资助项目 ( 98C0 79M)
