消渴安糖方对2型糖尿病气阴两虚证胃肠激素水平的影响

Effect of Xiaoke Antang prescription (消渴安糖方) on the levels of gastrointestinal hormones in patients with type 2 diabetes mellitus of Qi-Yin deficiency syndrome(气阴两虚证)

目的 :研究消渴安糖方对 2型糖尿病气阴两虚证患者空腹血清胃动素 (MTL )、胰高血糖素 (PG)、P物质 (SP)异常的影响 ,同时观察该方对 2型糖尿病植物神经病变气阴两虚证的疗效。方法 :将 90例 2型糖尿病气阴两虚证患者随机分为两组治疗 (分别为观察组和对照组 ) ,每组 4 5例 ;另设 30例健康人作为对照。观察组及对照组均给予常规糖尿病治疗 ,观察组另加用消渴安糖方每日 1剂 ,两组均治疗 1个月。采用放射免疫法检测治疗前后空腹血清 MTL、SP、PG;邻甲苯胺法测定空腹及餐后 2 h血糖 (BS) ;同时观察两组胃肠功能紊乱症状评分变化。健康人组仅测 1次血清 MTL、SP、PG。结果 :2型糖尿病气阴两虚证患者 MTL、PG值高于健康人组 ,SP则低于健康人组 ,均有非常显著性差异 (P均 <0 .0 1 )。治疗前后结果比较显示 ,观察组 MTL、PG、SP的异常以及胃肠功能紊乱症状有明显的改善 (P均 <0 .0 1 ) ,观察组治疗后 MTL、PG、SP和 BS改善也均优于对照组 (P均 <0 .0 5 )。结论 :消渴安糖方对 2型糖尿病气阴两虚证 MTL、SP和 PG异常有较好的改善作用 ,表明 2型糖尿病气阴两虚证与 MTL、SP和 PG异常有关 ;该方对 2型糖尿病植物神经病变证属气阴两虚证者有较好的治疗作用 。

Objective: To study the effect of Xiaoke Antang prescription on the serum motilin(MTL), pancreatic glucagon(PG) and substance P(SP) in patients with type 2 diabetes mellitus(DM) of QiYin deficiency syndrome , and to observe its therapeutic effects on patients with QiYin deficiency syndrome in diabetic neuropathy. Methods: Ninety cases with type 2 DM of QiYin deficiency syndrome were randomly divided into observation group and control group, 30 healthy people were selected as control. In addition to regular therapy of DM, the observation group were additionally treated with Xiaoke Antang prescription. The two groups were observed for a month. MTL, PG and SP were measured by radioimmunoassay before and after treatment, fasting blood sugar(FBS) and 2 hours postprandial blood sugar(PBS) were also measured. During the treatment the syndrome score of gastrointestinal function disorder were observed. MTL, PG and SP of the healthy control group were tested only one time. Results: The levels of MTL and PG in type 2 DM patients of the two groups were higher than the healthy normal group, but the level of SP was lower. There were significant differences between the levels of three above hormones of the two observation groups and that of the normal control group(all P <0 01), and there were great improvement in the abnormal of MTL, PG, SP and in the syndromes of gastrointestinal function disorder after treatment compared with those before treatment (all P <0 01). The improvement of blood sugar(BS) of the observation group was superior to that of the control group(all P <0 05). Conclusion: Xiaoke Antang prescription can betterly improve the abnormal of MTL, PG and SP of QiYin deficiency syndrome in patients with type 2 DM, it proves that QiYin deficiency syndrome in type 2 DM has relativity with the abnormal of MTL, PG and SP. Xiaoke Antang prescription can provide better therapeutic effects on QiYin deficiency syndrome in patients with diabetic neuropathy, and has certainly auxiliary effect on reducing the level of BS.