摘要
目的 :探讨肺心合剂对野百合碱 (MCT)诱发肺动脉高压模型大鼠的治疗作用。方法 :利用 MCT制备大鼠肺动脉高压模型。雄性 Wistar大鼠 6 0只 ,随机分为正常对照组、模型组、硝苯吡啶组以及肺心合剂高、中、低剂量组 ,每组 1 0只。分别于制模后 1 4 d灌胃相应药物 ,连续用药 8d。采用右心导管术测定肺血流动力学参数 ,计算平均肺动脉压 (m PAP) ;处死动物后取肺脏称取肺湿质量 ,计算肺渗出指数和右心肥厚指数。结果 :肺心合剂和硝苯吡啶都能明显降低肺动脉高压大鼠的 m PAP、肺渗出指数和右心肥厚指数 (P<0 .0 5或 P<0 .0 1 ) ,以肺心合剂大剂量组效果最好。结论 :肺心合剂能有效降低肺动脉高压 。
Objective: To explore the effect of Feixin mixture on pulmonary hypertension (PAHT). Methods: Adult male Wistar rats were given a single dose of subcutaneous monocrotaline(MCT, 50 mg/kg ) to induce the model of pulmonary hypertension. Sixty cases were randomly divided into normal contral group, PAHT mold group, FXM group and nifedipine group ( n =10). Then the rats were treated with gastric infusion of normal saline, FXM or nifedipine in 14th days respectively. The parameters of pulmonary hemodynamics were monitored by Gould3400 polygraph system through the cannulation of polyvinyl tube. Right ventricle and left ventricle added with interventricular septum weight ratio, the lung wet weight and body weight ratio were measured. Results: FXM and nifedipine significantly inhibited the progression of pulmonary artery pressure and decreased the right heart index and reduced the seepage out of the lung ( P <0 05 or P <0 01). The effect of high dose FXM group were better. Conclusion: FXM is able to reduce the pulmonary hypertension and improved the heart function.
出处
《中国中西医结合急救杂志》
CAS
2003年第3期164-166,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
四川省中医药管理局科研基金资助项目 ( 960 3 1)
