细菌群体感应机制与动植物病原菌的致病力

Bacterial quorum sensing and pathogenicity of plant and animal bacterial pathogens

N 酰基高丝氨酸内酯 (AHLs)作为信号分子介导的细菌群体感应机制参与许多生物学功能的调节 ,当侵染动植物寄主组织的病原菌繁殖到一定量时 ,细菌本身产生的AHLs积累到临界浓度 ,AHLs与胞内特异受体结合 ,启动致病因子的表达。利用AHLs降解酶和AHLs类似物的特性 ,干扰和破坏病原菌的AHLs 群体感应机制 。

Bacterial N Acyl L homoserine lactones (AHLs) mediated quorum sensing is involved in the regulation of diverse biological functions. As the bacterial pathogen population density increases, AHLs concentration secreted by pathogen reaches a threshold and then interacts with their intracellular receptors and triggers expression of virulence genes. It is a promising approach to biologically control bacterial diseases in plant and animal by manipulating bacterial AHL quorum sensing with AHLs degrading enzyme and AHL homology.