血管紧张素转换酶基因插入/缺失多态性与中国汉族人脑梗死关系的Meta分析

Meta-analysis on the relationship between insertion/deletion polymorphism of the angiotensin-con-verting enzyme gene and cerebral infarction in Chinese population

目的 系统评价中国汉族人血管紧张素转换酶 (ACE)基因插入/缺失 (D/I)多态性与脑梗死的关联性。方法 联合运用3种有效文献检索途径 ,全面检索ACE基因插入/缺失多态性与脑梗死病例对照研究的相关文献 ,剔除不符合要求文献 ,9个相关研究被用于Meta分析。各研究间存在异质性 ,故采用随机效应模型进行数据合并 ,以脑梗死组和对照组基因型分布的比数比(OR)为统计量。结果 共2066例脑梗死和对照者被用于Meta分析 ,数据合并后ACEDD基因型与ID +II基因型的OR为1.58,95 %可信区间为1.04～2.41。 结论 中国汉族人ACE基因缺失型是脑梗死的危险因素。

Objective To study the association of the insertion(I)/deletion(D)polymorphism of an-giotensin-converting enzyme(ACE)gene with cerebral infarction in Chinese population.Methods Three computerized databases were searched for all publications relating to case-control studies using the ACE I/D variant in cerebral infarction.Nine relevant studies were identified and a meta-analysis was conducted.Der Simonian-Laird randomeffect model was used to estimate the odds ratio(OR)and to determine whether the DD genotype could predict the outcome in either genetically dominant or recessive model.Results Total2066cases with cerebral infarction and controls were used in the meta-analysis.The pooled odds ratio of ACE DD genotype vs ID+II was1.58(95%CI:1.04-2.41)(P<0.01).Conclusion The meta-analysis shows that the DD genotype is a risk factor for cerebral infarction in Chinese population.