海洛因依赖者活动性巨细胞病毒感染和红细胞免疫功能检测

DETECTION OF ERYTHROCYTE IMMUNE FUNCTION IN HEROIN ADDICTS AND HEROIN ADDICTS WITH ACTIVE CYTOMEGALOVIRUS INFECTION

目的:了解海洛因依赖、红细胞免疫及巨细胞病毒感染之间的关系。方法:采用红细胞酵母菌花环实验检测43例海洛因依赖者及11例伴有活动性巨细胞病毒感染的海洛因依赖者红细胞免疫功能。结果:与正常对照组相比海洛因依赖者和伴有活动性巨细胞病毒感染的海洛因依赖者红细胞C_(3b)受体花环率(RC_(3b)R)、红细胞免疫粘附促进因子活性(RFER)、红细胞促中性粒细胞吞噬率(ERPN)显著下降(P<0.01),红细胞免疫复合物花环率(RICR)、红细胞免疫粘附抑制因子活性(RFIR)明显升高(P<0.01)。海洛因依赖者活动性巨细胞病毒感染率明显高于正常对照组(P<0.01),伴有活动性巨细胞病毒感染的海洛因依赖者与单纯海洛因依赖者相比,其红细胞C_(3b)受体花环率进一步降低(P<0.05),而红细胞免疫复合物花环率(RICR)则进一步增高(P<0.01)。结论:长期吸食海洛因可以导致红细胞免疫功能的明显损害,巨细胞病毒是海洛因依赖者的常见机会性感染因子,巨细胞病毒的活动性感染可以进一步损伤红细胞免疫功能。

Objective: To assess the interrelations of heroin abuse, erythrocyte immune function, and cytomegalovirus infection. Methods: The alteration of the erythroytic immune function in 43 heroin addicts and 11 heroin addicts with active cytomegalovirus infection (ACI) were observed with red cell yeast rosette test. Results: Compared with the control group, the red cell C3b receptor (RC3bR) , red cell C3b receptor flower enhancing rate(RFER) and enhancing rosette rate of red cell in neutropinls(ERRN) significantly decreased; red cell immune complex rosette rate(RICR) and red cell C3b, receptor flower ininbiting rate(RFIR) markedly elevated in heroin addicts. The frequency of active cytomegalovirus infections was ingher in heroin addicts than in the control group. Compared with heroin addicts, RC3bR further decreased and RICR further elevated in active cytomegalovirus infected heroin addicts. Conclusion: The long term abuse of heroin may lead to an obvious damage of erythrocytic immune function, and cytomegalovirus is one of the important opportunistic infections in heroin addicts and the infection may cause further damage on their erythrocytic immune function.