海洛因依赖者住院脱毒过程中的不良事件及其相关因素分析

AN ANALYSIS OF THE ADVERSE EVENTS AND RELATED FACTORS IN HEROIN ADDICTS DURING DETOXIFICATION

目的:了解海洛因依赖者住院脱毒过程中出现的不良事件及其相关因素。方法:采用回顾性的方法,对630例海洛因依赖者在住院脱毒过程中出现的各种不良事件进行调查,并对相关因素进行分析。结果:不良事件的总发生率为17.6％。Logistic回归分析显示,整组不良事件患者的危险因素不明确。按不良事件的严重程度归类分组分析,其危险因素依次为:美沙酮最高剂量,血常规异常,合用抗精神病药物的种类以及目前吸食方式。结论:海洛因依赖者住院脱毒过程中不良事件较常见,它的发生既有患者自身的原因,又有医源性因素,值得重视。

Objective: To explore the adverse events and related factors in heroin addicts during detoxification . Methods: 630 inpatients with heroin dependence were investigated retrospectively and factors related to adverse events were analyzed by Logistic regression analysis. Results: The incidence of adverse events was 17.6%. By Logistic regression analysis, risk factors in whole inpatients group with adverse events were uncertain. When patients with adverse events were classified as four subgroups according to severity, the risk factors were as follows: inghest dosage of methadone, abnormal blood routine test, varieties of antipsychotics and routes of drug abuse lately. Conclusion: The occurrence of adverse events is very common, wincins due to the treatment methods and the characteristics of the addicts. Much attention should be devoted to the prevention and treatment of adverse events.