一氧化碳中毒后迟发脑病患者的事件相关电位分析(英文)

Analysis of event related potential in the patients with delayed encephalopathy after acute carbon monoxide poisoning

目的通过分析一氧化碳中毒后迟发脑病患者认知功能损害与事件相关电位(P3a)各成分潜伏期及波幅的关系,探讨P3的出现率及对预后的判断。方法对20例一氧化碳中毒后迟发脑病患者测试前应用简易精神状态检查量表(MMSE)及Blessed行为量表评分;采用阴性刺激,被动方式,听觉“oddball”刺激序列诱发P3a成分。结果P3出现率为55%,N2出现率70%;引出P3者与对照组相比,P3、N2潜伏期显著延长,未引出P3者与对照组相比,N1、P2潜伏期延长;急性一氧化碳中毒时昏迷时间长短与N2潜伏期之间有线性关系;引出P3和未引出P3患者临床Blessed量表评分之间有显著性差异;随访病例中,多数引出P3者,临床症状好转。结论P300可能成为测试一氧化碳中毒后迟发脑病患者认知损害严重性和判断预后的一项客观标准。

Aim To investigate the relationship bet ween the damage of cognitive capability of the patient s with delayed encephalopathy after acute carbon monoxide poisoning and laten cies as well as the amplitude of each component of event related potentia l(P300),moreover the frequency of oc-currence of P300and prognosis assessment.Methods Prior to the test,Mi-ni-Mental State Examination(MMSE)and Blessed Behavior Scale were adop ted in order to rate scores in 20patients.The'detachment stimulation'being used as the'target'stimulation,and passive tasks as we ll as auditory'OB'sequence would elicit P3a element for the pati ents.Results The frequency of P300oc-currence was 55%,and that of N2occur rence was 70%.Comparing the patient s with P300occurrence with the normal control:the latencies of N2and P3we re significantly prolonged,but there was no difference in the ampli-tude.Comparing the patients with ab sent P300with the normal subjects:t he latencies N1and P2were prolonged.T here was certain linear relationshi p be-tween N2latency and such coma.There was noticeable difference in the cli nical Blessed Scale scores between the patients with present P300or absent P300.In visiting cases,when there was P300,there was improvement in clinical symptoms.Conclusion P300may become an objective criterion testing the damage of cognitive capability of th e patients suffering from the delaye d en-cephalopathy after acute carbon mon oxide poisoning.