葛根黄酮对去卵巢大鼠肝脏脂代谢的影响

Effect of Pueraria Flavone on Liver Lipid Metabolism in Ovariectomized Rats

目的 :研究葛根黄酮对去卵巢大鼠肝脏脂代谢的作用。方法 :用成年雌性去卵巢大鼠模型 ,以葛根黄酮灌胃 ,观察药物对大鼠体重、腹部脂肪量、子宫湿重及肝脏总胆固醇(TC)、甘油三酯 (TG)的影响。结果 :模型组大鼠去卵巢 6周后体重明显增加 ,腹部脂肪堆积 ,肝内甘油三酯及胆固醇水平提高 ,子宫萎缩。服葛根黄酮后 ,对上述指标均有不同程度的降低作用。结论 :葛根黄酮具有一定的雌激素样作用 。

Objective: To study the action of Pueraria Flavone on liver lipid metabolism in ovariectomized rats. Methods: Adult female ovariectomized model rats were used in this experiment. One week after operation 40 ovariectomized rats were given Pueraria Flavone by oral administration for 5 weeks respectively (10g/kg). The effect of drug on weight, the amount of abdominal fat, wet weight of uterus, liver total cholesterol and triglycerides were observed after the rats were killed. Results: Rats in the model group gain weight markedly and fat piling up in the abdomen and liver triglycerides and cholesterol increasing and uterus atrophy ovariectomy six weeks later. The above-noted indices were relieved in different degree after being taken Pueraria Flavone. Conclusion: Pueraria Flavone has some estrogen-like action and may be helpful to prevent and treat menopause syndrome.