磁共振成像在肝癌介入治疗短期效果评价中的价值

Early findings after transcatheter arterial chemombolization of hepatocellular carcinoma with MR imaging

目的 观察肝癌患者经导管动脉化疗栓塞(TACE)治疗后MRI信号及ADC值的变化.方法 回顾性分析35例肝癌患者在TACE术前和术后4～6周,分别进行常规MR检查及弥散成像,观察术前、术后T1WI、T2WI信号及病灶强化特征变化,测量病灶ADC值,并比较上述各指标的差异.结果 15个术后无活性病灶及27个有活性病灶T1WI信号比较差异无统计学意义(x2=0.175,P＞0.05),而在T2WI信号上表现差异有统计学意义(x2=4.698,P＜0.05);TACE治疗术后无活性病灶ADC值较术前明显升高[(1.72±0.48 ×10-3)mm2·s-1],差异有统计学意义(P＜0.05),TACE治疗后尚存活性病灶ADC值较术前无明显升高[[(1.19 ±0.25×10-3)mm2·s-1],差异无统计学意义(P＞0.05).结论 磁共振常规成像及弥散成像能够敏感的观察TACE术前术后信号变化,可用于肝癌TACE早期疗效评价.

Objective To investigate the value if MRI imaging in early detection of finding following TACE of hepatocellular carcinoma. Methods Thirty five patients with HCC were evaluated by retrospection,All patients underwent routine examination and diffusion weighted imaging of MR imaging were at pre-TACE and 4 ~ 6weeks after TACE. To observe finding of characteristics in T1WI、T2WI and enhanced degree,to measure ADC of HCC,Statistical analysis using SPSS13. 0,and least significant difference test(t-teast)and Chi-square test were utilized. Results There are no significant difference between 15 patients without active lesions and 27 active lesions in T1WI signal(χ2= 0. 175,P > 0. 05)and there are significant difference T2WI signal between 15 patients without active lesions and 27 active lesions(χ2= 4. 698,P < 0. 05). TACE treatment patients without active lesions ADC value was significantly higher than the preoperative(1. 72 ± 0. 48 × 10-3mm2·s-1),the difference was statistically significant(P <0. 05),Activity lesion ADC value after TACE was significantly higher than the preoperative(1. 19 ± 0. 25 × 10-3mm2·s-1),the difference was not statistically significant(P> 0. 05). Conclusion Conventional magnetic resonance imaging and diffusion imaging can be sensitive to signal changes observed and evaluate the efficacy in early of TACE.