HCV核心抗原检测在血液透析患者HCV感染中的临床价值

Clinical significance of HCV core antigen in the screening of HCV infection in hemodialysis patients

目的 探讨丙型肝炎病毒(HCV)核心抗原检测方法在血液透析人群HCV感染筛查中的临床价值.方法 应用HCV Ag定量检测、抗-HCV和HCV RNA检测等3种方法,对138例进行血液透析维持治疗的慢性肾功能衰竭患者进行HCV感染筛查,比较各种检测方法HCV感染符合率、假阳性率、假阴性率.结果 138例血液透析患者,HCV Ag阳性19例(13.77％),抗-HCV阳性10例(7.25％),HCV RNA阳性25例(18.12％).HCVAg定量检测HCV检出率(13.77％)高于抗-HCV(7.25％);与HCV RNA检测结果比较,HCV Ag检测符合率(94.2％)高于抗-HCV检测符合率(86.96％).所有抗-HCV阳性标本(S/CO:10.16 ～ 167.41)应用HCV Ag均可检出.结论 HCV Ag定量检测可以提高血液透析人群HCV感染的检出率.

Objective To assess the application value of three different detection markers in the screening of HCV infection in hemodialysis( HD) patients. Methods 138 chronic renal failure patients undergoing hemodialysis were enrolled in the study. HCV Ag,anti-HCV and HCV RNA were detected in the 138 serum samples. HCV infection ratio assessed by these makers was compared. Results 19 case (13.77%) of 138 chronic renal failure patients undergoing hemodialysis were HCV Ag positive;10 case( 7.25%) were anti-HCV positive and 25 case( 18. 12%) were HCV RNA positive. The positive rate of HCV was higher with HCV Ag assay than that with anti-HCV assay(13.77% vs.7.25%).Compared with the result of HCV RNA assay,the positive rate of HCV Ag(94.2%) assay was higher than that in anti-HCV assay( 86. 96%). All anti-HCV positive sample( S/CO: 10. 16 ~167. 41) were also positive by HCV Ag. Conclusion Compared with anti-HCV,HCV RNA,the HCV Ag assay provides a higher detection rate for HCV infection in HD patients.