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RASSF6 mRNA在胃癌组织中的表达及临床意义

The expressions of RASSF6 mRNA in gastric cancer and clinical significance
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摘要 目的探讨RASSF6 mRNA在胃癌组织中的表达及与临床病理特征的关系。方法采用荧光定量RT-PCR法检测RASSF6 mRNA在100例新鲜胃癌组织和癌旁组织中的表达情况,并分析与临床病理特征的关系。结果胃癌中RASSF6 mRNA表达量明显低于癌旁组织(P<0.05)。RASSF6 mRNA的表达量与肿瘤的浸润深度、淋巴结转移、临床分期及分化程度有相关性(P<0.05)。结论 RASSF6在胃癌的发生发展中发挥抑癌作用,其表达与胃癌的侵袭转移有关。 Objective To detect the expression of RASSF6 mRNA in gastric cancer,and to analyze the correlation between RASSF6 mRNA with clinicopathologic feature. Methods Real- time fluorescence quantitative PCR was performed to analyze the expression of RASSF6 mRNA levels in 112 samples of gastric cancer and the paired adjacent normal mucosa. Results The expression of RASSF6 mRNA were decreased in gastric cancer tissues compared with the adjacent normal mucosa( P < 0. 05); The expression of RASSF6 mRNA were associated with the infiltration depth,lymph node metastasis,clinical stage and differentiation degree( P < 0. 05).Conclusion RASSF6 might be a new tumor suppressor gene in gastric cancer. It could play a negative regulatory role in occurrence and development of gastric cancer.
作者 陈萍 赵岳阳 李淑璟 刘新兰
机构地区 宁夏医科大学总医院肿瘤医院肿瘤内科 宁夏医科大学 宁夏医科大学总医院儿科
出处 《宁夏医学杂志》 CAS 2016年第5期406-407,共2页 Ningxia Medical Journal
基金 宁夏自然科学基金资助项目(NZ11271) 宁夏卫生厅科研资助项目(2013106)
关键词 胃癌 RASSF6 实时荧光定量 Gastric Cancer RASSF6 Real-time fluorescence quantitative RT-PCR
分类号 R735.2 [医药卫生—肿瘤]
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参考文献11

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宁夏医学杂志
2016年 第5期

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