脑微出血与认知功能障碍的相关性研究

Correlation study of cerebral microbleed and cognitive impairment

目的探讨脑微出血(CMB)与认知功能障碍(CI)、血同型半胱氨酸(Hcy)、尿酸、胆固醇、甘油三酯(TG)的相关性。方法收集就诊的非急性卒中患者,根据诊断及排除标准分为脑微出血组与对照组。在入院后次日对患者进行MOCA评分,并抽取清晨空腹静脉血行血Hcy、尿酸、胆固醇及TG测定,比较2组MOCA评分、血Hcy、尿酸、胆固醇及TG水平;脑微出血组根据病灶数量分为1级~3级,比较3组之间MOCA评分的差异。结果脑微出血组与对照组比较,MOCA评分低于对照组(P<0.05);Hcy、尿酸、胆固醇均高于对照组,差异有统计学意义(P<0.05);2组TG水平差异无统计学意义(P>0.05)。不同程度脑微出血组之间MOCA评分比较,差异有统计学意义(P<0.05)。结论 CMB可能与CI、高同型半胱氨酸血症、高尿酸血症、高胆固醇血症存在相关性;CMB病灶的数量可能与CI程度存在相关性。

Objective To explore the correlation of cerebral microbleed and Cognitive impairment,blood homocysteine( Hcy),uric acid,cholesterol,triglyceride( TG). Methods The patients were divided into cerebral microbleed group and the control group according to diagnosis and exclusion criteria. The level of MOCA score,blood Hcy,uric acid,cholesterol and TG were compared between two groups. Cerebral microbleed group was divided into level 1,level 2,level 3 according to the number of lesions and the MOCA score was compared among the three groups. Results Compared with cerebral microbleed group and the control group,MOCA score of cerebral microbleed group was lower than that in the control group( P < 0. 05). Hcy,uric acid and cholesterol of cerebral microbleed group was higher than that in the control group( P < 0. 05). The difference of TG was no significant( P > 0. 05). There was significantly difference of MOCA score between different degree of cerebral microbleed group( P < 0. 05). Conclusion Cerebral microbleed may be related to cognitive impairment,high homocysteine levels,high uric acid hematic disease,high cholesterol. The number of cerebral microbleed lesions may be related to the degree of cognitive impairment.