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房颤患者NT-proBNP、MMP-9与左房结构的相关性研究 被引量:1

Study on the correlation between NT-proBNP,MMP-9 and the left atrial structural in patients with atrial fibrillation
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摘要 目的探讨房颤患者氨基末端脑钠肽前体(NT-proBNP)、基质金属蛋白酶-9、(MMP-9)与左房结构的关系。方法选取房颤患者120例(其中阵发性房颤患者62例,持续性房颤患者58例)及健康对照组69例,测定左房前后径、左房最大容积、左房最小容积,计算左房容积指数,检测NT-proBNP、MMP-9水平,比较各组差异及相互关系。结果阵发房颤组和持续房颤组左房前后径、左房最大容积、左房最小容积、左房容积指数、NT-proBNP、MMP-9指标明显高于对照组(P<0.05);持续房颤组左房最大容积、左房最小容积、左房容积指数、NT-proBNP、MMP-9指标高于阵发房颤组(P<0.05),左房前后径略高于阵发房颤组,但差异无统计学意义(P>0.05);直线相关分析显示阵发房颤组和持续房颤组NT-proBNP、MMP-9与左房前后径、左房最大容积、左房最小容积、左房容积指数呈正相关;NT-proBNP与MMP-9呈正相关。结论房颤患者NT-proBNP、MMP-9与左房结构变化密切相关。 Objective To investigate the correlation between NT-proBNP,MMP-9 and the left atrial structural in patients with atrial fibrillation.Methods 120 cases of patients with atrial fibrillation were enrolled,who were classified into the paroxysmal atrial fibrillation group(n=62)and the persistent atrial fibrillation group(n=58).Sixty-nine healthy subjects was as control group.Left atrial dimension(LAD),left atrial maximum volume(LAVmax),left atrial minimum volume(LAVmin)and left atrial volumeindex(LAVI)were measured.The NT-proBNP and MMP-9 were detected.The differences and correlation among NT-proBNP,MMP-9 and the left atrial structural were analyzed.Results The NT-Pro BNP,MMP-9,LAD,LAVmax,LAVmin and LAVI in atrial fibrillation patients were significantly higher than that in the control group(P<0.05).The NT-Pro BNP,MMP-9,LAVmax,LAVmin and LAVI l in the persistent atrial fibrillation group were significantly higher than that in the paroxysmal atrial fibrillation group(P<0.05).Two variables linear correlation analysis showed that the NT-pro BNP,MMP-9 were positively correlated with LAD,LAVmax,LAVmin and LAVI in atrial fibrillation group,and the NT-Pro BNP was positively correlated with MMP-9.Conclusion The NT-pro BNP and MMP-9 are significantly correlated with the left atrial structural in patients with atrial fibrillation.
作者 刘怀荣 安雅萍 刘婧 崔建钧 贾武梅 胡红梅 LIU Huairong;AN Yaping;LIU Jing;CUI Jianjun;Jia Wumei(The First People’s Hospital of Yinchuan,Yinchuan 750001,China)
出处 《宁夏医学杂志》 CAS 2019年第5期391-394,共4页 Ningxia Medical Journal
基金 宁夏自然科学基金计划项目(NZ16220) 银川市应用研究开发计划项目(YCKJJ-2016-22)
关键词 房颤 氨基末端脑钠肽前体 基质金属蛋白酶-9 左房结构 Atrial fibrillation N-terminal pro-brain natriuretic peptide Matrix metallopoeinases-9 Left atrial structural
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  • 1杨延宗,黄从新,高连君,刘少稳,杨东辉,林治湖.阵发性心房颤动大静脉电隔离后肌袖内自发电活动的特点[J].中华心律失常学杂志,2004,8(3):146-150. 被引量:20
  • 2LIUJie,HUANGCong-xin,BAOMing-wei,WANGTeng.Ectopic activity induced by elevated atrial pressure in rabbit pulmonary vein in vitro[J].Chinese Medical Journal,2005(14):1210-1213. 被引量:12
  • 3龙德勇,刘兴鹏,马长生,董建增,赵文度,方冬平.心房颤动射频消融术中应用丙泊酚深度镇静的临床观察[J].中华心律失常学杂志,2006,10(5):338-341. 被引量:14
  • 4喻荣辉,马长生,董建增,刘兴鹏,龙德勇,康俊萍,方东平,汤日波,胡福莉,何小魁.电解剖标测和磁共振影像融合技术指导导管消融心房颤动的有效性研究[J].中华心血管病杂志,2007,35(11):1029-1033. 被引量:13
  • 5January CT,Wann LS,Alpert JS,et al.2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation a report of the American College of Cardiology/American Heart Association task force on practice guidelines and the Heart Rhythm Society[J].Circulation,2014;130(23):e199.
  • 6Calkins H,Heinz H,Cappato R,et al.HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation:recommendations for patient selection,procedural techniques,patient management and follow-up,definitions,endpoints,and research trial design[J].Heart Rhythm,2012;9:632-96.
  • 7Hof I,Arbab-Zadeh A,Dong J,et al.Validation of a simplified method to determine left atrial volume by computed tomography in patients with atrial fibrillation[J].Cardiol,102(2008):1567-70.
  • 8Letsas KP,Filippatos GS,Pappas LK,et al.Determinants of plasma NT-pro-BNP levels in patients with atrial fibrillation and preserved left ventricular ejection fraction[J].Clin Res Cardiol,2009;98(1):101-6.
  • 9Hussein AA,Saliba WI,Martin DO,et al.Plasma B-type natriuretic peptide levels and recurrent arrhythmia after successful ablation of lone atrial fibrillation[J].Circulation,2011;123:2077-82.
  • 10Kallergis EM,Manios EG,Kanoupakis EM,et al.Effect of sinus rhythm restoration after electrical cardioversion on apelin and brain natriuretic Peptide prohormone levels in patients with persistent atrial fibrillation[J].Am J Cardiol,2010;105(1):90-4.

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