氧甾酮与冠状动脉粥样硬化狭窄的临床研究

A clinical study of plasma oxysterol level in patients with coronary atherosclerotic stenosis

目的探讨冠状动脉粥样硬化患者血清中氧甾酮水平与冠状动脉血管病变的临床关系。方法收集治疗的冠心病患者300例,将其分为3组,每组100例。A组冠状动脉狭窄≥75%(重度狭窄),B组冠状动脉狭窄≥50%且<75%(中度狭窄),C组冠状动脉狭<50%(轻度狭窄),比较3组患者血清中氧甾酮水平。结果 A组患者血清中氧甾酮水平明显高于B组和C组(P<0.05),B组患者氧甾酮水平高于C组(P<0.05)。结论血清氧甾酮水平与冠状动脉狭窄的严重性相关,氧甾酮水平随着冠状动脉狭窄程度的增加而升高。

Objective To investigate the relationship between the plasma oxysterone levels and coronary artery disease in patients with coronary atherosclerosis.Methods 300 patients with coronary heart disease treated in the department cardiology of our hospital were collected and divided into three groups,100 patients in each group:group A(with coronary artery stenosis≥75%,severe stenosis),group B(coronary artery stenosis≥50%and<75%,moderate stenosis),group C(coronary artery stenosis<50%,mild stenosis).The levels of oxysterone in serum of the three groups were compared.Results The level of oxysterone in group A was significantly higher than that in group B and C(P<0.05)and the level of oxysterone in group B was higher than that in group C(P<0.05).Conclusion The serum level of oxysterone is associated with the severity of coronary artery stenosis and it increased with the degree of coronary artery stenosis.