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VEGF在肺癌组织中的表达及临床意义

EXPRESSION OF P53 AND VEGF IN LUNG CANCER AND THEIR CLINICAL SIGNIFICANCE
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摘要 目的 :探讨血管内皮生长因子在肺癌中的表达情况与肺癌病理生物学行为之间的关系。方法 :采用免疫组化 SP法检测 4 7例肺癌组织和 10正常肺组织中 VEGF的表达水平。结果 :肺癌组织中 VEGF的表达明显高于正常肺组织 (P<0 .0 0 5 ) ,P5 3、VEGF表达与肺癌的分化程度、淋巴结转移及 P- TNM分期密切相关 (P<0 .0 5 ) ,与患者的性别、年龄、肿瘤大小及组织类型无关 (P>0 .0 5 )。结论 :检测肺癌组织中 VEGF的表达水平有助于了解肿瘤的生物学行为 。 Objective:To explore the relationship between expression of VEGF and pathological factors.Methods:The expression of VEGF were detected in 47 lung cancer lesions,10 cases normal lung tissues by immunohistochemical staining(SP).Results:VEGF expressions were significantly higher in lung cancer than those in normal tissues(P<0.01).The expression of VEGF in lung cancer was closely related to differentiation grade(P<0.05),lymph node metastasis and P TNM stages,but not related to sex,age,tumor size and histological types(P>0.05).Conclusion:VEGF expressions in lung cancer is helpful to evaluate the biological behavior of lung cancer,and served as a valuable factor for estimating patients prognosis.
出处 《承德医学院学报》 2003年第2期98-99,共2页 Journal of Chengde Medical University
关键词 VEGF 肺癌 临床意义 病理生物学 血管内皮生长因子 淋巴结转移 Lung cancer VEGF Immunohistochemistry
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