糖尿病小鼠免疫状态的实验研究

THE STUDY OF IMMUNE STATUS ON DIABETIC MICE

目的 :探讨糖尿病小鼠与正常小鼠细胞免疫和体液免疫是否有差别。方法 :用链脲佐菌素诱发小鼠糖尿病 ,在成模后取外周血分别测定 14只正常小鼠和 16只糖尿病小鼠 T细胞亚群及免疫球蛋白的含量。结果 :糖尿病小鼠与正常小鼠之间 CD4 +、CD8+ T细胞与免疫球蛋白 Ig A、M、G经 t检验 P>0 .0 5 ,无明显差异。结论

Objective:To observe the immune status of diabetic mice.Methods:Kunming mice were induced to diabetes by intraperitingeal injection Streptozotocin.After succeded we measured 14 normal mice and 16 diabetic mice the T cell subsets and immunoglobulin in peripheral blood.Results:The level of CD4 +,CD8 +T.cells,IgG,IgA,IgM was no significantly difference in the two groups.Conclusion:The immune status at diabetic mice and normal mice has no difference.