摘要
目的:观察泮托拉唑合旋覆代赭汤治疗反流性食管炎(RE)的疗效。方法:60例经内镜证实的RE患者,随机分为两组,治疗组30例,予以泮托拉唑40mg,1次/d口服,同时服用中药旋覆代赭汤100ml,3次/d口服;对照组30例,予以奥美拉唑20mg,1次/d口服,同时服用旋覆代赭汤100ml,3次/d,疗程均为4周。两组分别记录治疗前后反酸、烧心、胸痛、胃胀等症状积分,于4周后复查内镜。结果:两组治疗后1周,烧心、反酸、胸痛、胃胀等症状积分较治疗前均明显下降(均P<0.01),4周后达到缓解。治疗组内镜下食管炎治愈率为80.0%,有效率为93.3%,与对照组(76.7%及90.0%)比较,差异无显著性意义(P>0.05)。结论:国产泮托拉唑治疗RE与奥美拉唑的疗效相同。
Objective: To investigate the effect of pantoprazole and Xuanfu Daizhe decoction (XDD) on reflux esophagitis. Methods: Sixty patients with endoscopically proven reflux esophagitis were randomly divided into two groups. In the treatment group of thirty patients , pantoprazole was given 40 mg once a day for 4 weeks and XDD was given 100 ml three times daily. In the control group, omeprazole was given 20 mg once a day for 4 weeks and XDD was given 100 ml three times daily. Reflux symptoms including regurgitation, heartburn, chest pain and gastrotympanites were e-valuated before and after the treatment. At the end of the fourth week, endoscopy exam was reexam-ined. Results: One week after the treatment, the symptom scores of regurgitation, heartburn, chest pain and gastrotympanites decreased significantly in both groups ( P <0. 01). Four weeks after treatment , the symptoms remitted. There was no significant difference between the two groups( P > 0. 05 ). At the end of the treatment, from endoscopy healing rate and effective rate was 80. 0 % and 93. 3 % respectively in the treatment group, being similar to those of 76. 7 % and 90. 0 % in the control group ( F > 0. 05). Conclusion: The effect on reflux esophagitis of pantoparzole (produced in China, with trade name Taimeinike) and omeprazole were the same.
出处
《中国中西医结合消化杂志》
CAS
2003年第3期171-172,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion