泮托拉唑联合西沙必利治疗反流性食管炎

Pantoprazole Combined with Cisapride in the Treatment of Reflux Esophagitis

目的:观察泮托拉唑联合西沙必利治疗反流性食管炎的疗效。方法:选取107例经内镜确诊为RE的患者随机分为观察组(54例)和对照组(53例),观察组:泮托拉唑40mg,每日1次,西沙必利5mg,每日3次;对照组:雷尼替丁150mg,每日2次,西沙必利5mg,每日3次。于治疗后8周观察临床症状改善情况,并复查胃镜,观察镜下RE愈合率。结果:观察组临床有效率92.6%,镜下有效率90.7%;对照组临床有效率73.5%,镜下有效率71.6%,两组比较差异有显著性。结论:泮托拉唑联合西沙必利治疗反流性食管炎疗效明显优于雷尼替丁联合西沙必利,是一种安全、有效的治疗方案。

Objective:To observe the effect of pantoprazole combined with cisapride in the treatment of reflux esophagitis (RE). Method :107 cases who diagnosed as RE by endoscopy were randomly divided into observation group (54 cases) and control group (53 cases). Observation group was given 40mg of pantoprazole (once a day) and 5mg of cisapride (3 times per day),while control group was given 150mg of ranitidine (twice a day) and 5mg of cisapride (3 times per day). The improvement of clinical symptoms and curative rate of RE were observed after 8w. Result: The clinical effective rates were 92.6% in observation group and 73.5% in control group,while effective rates under endoscopy were 90.7% in observation group and 71.6% in control group. The difference was significant. Conclusion: Pantoprazole combined with cisapride is superior to the combination of pantoprazole and ranitidine in the treatment of reflux esophagitis. It is an effective and safe therapy.