自体外周血干细胞移植治疗急性白血病的疗效观察

An analysis of autologous peripheral blood stem cell transplantation for acute leukemia

目的:探讨自体外周血干细胞移植(APBSCT)治疗急性白血病(AL)的临床效果。方法:APBSCT治疗AL患者11例,其中急性髓细胞白血病7例,急性淋巴细胞白血病4例;AML患者采用BU/CTX方案(马利兰+环磷酰胺)和AL患者采用CTX/VP16/TBI方案(环磷酰胺+足叶乙甙+TBI)预处理。结果:11患者均获造血功能重建,无严重移植相关并发症;与常规化疗相比,APBSCT可延长移植患者无病生存期及总生存期,3年及5年生存率AML组为71.42%和42.85%,AL组为25.00%和0。结论:APBSCT是治疗AL和改善其预后的一种重要手段。

Objective To obseve the efficacy of autologous peripheral blood stem cell transplantation (APBSCT) on treating acute leukemia patients.Methods 7 case of acute leukemia myeloid (AML) patients and 4 case of acute lymphoblastic leukemia(ALL) patients received APBSCT,AML patients and ALL patients were treated with conditioning regimen of BU/CTX and CTX/VP16/TBI. Results Hematologic recovery was achieved in 11 case,none was serious transplantation related complications;comparing to conventional chemotherapy,APBSCT can prolong the patients'disease-free survial (DFS) and overall survival (OS),the 3 and 5-year OS rates were 71.42% and 42.85% for AML,25.00% and 0 for ALL. Conclusion APBSCT treatment of AL has promising efficacy and higher safety.