防己黄芪胶囊对高血压患者血清NO、eNOS水平的影响

Effects of Fangjihuangqi Capsule on Serum Nitric Oxide and Endothelial Nitric Oxide Synthase in Hypertension

目的:观察防己黄芪胶囊对高血压患者血清一氧化氮(NO)及内皮型一氧化氮合酶(eNOS)的水平变化,探讨其调节血压的可能机制。方法:中医辨证属痰湿证高血压患者94例,随机分为两组,对照组46例,予络活喜口服;治疗组48例,予防己黄芪胶囊加络活喜口服;疗程均为2个月,治疗前、中、后期分别检测两组患者血清NO、eNOS水平并作统计学分析。结果:治疗后治疗组与对照组NO、eNOS水平均高于治疗前,差异具有统计学意义(р【0.01);2个月后治疗组NO、eNOS均高于对照组,差异具有统计学意义(р【0.05),且上升程度与治疗的时间呈正相关。结论:防己黄芪胶囊上调高血压患者血清NO、eNOS水平,从而可能对患者血压产生调节作用。

Objective To test the change of serum nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) level in patients with hypertension, which classified as phlegmatic hygrosis, before and after taking Fangjihuangqi capsule, so as to study the mechanism of it on treatment of hypertension. Methods 94 patients with primary hypertension classified as qi asthenia and pglegmatic hygrosis were grouped randomly into two groups: Treatment (T group,n=48) and Control (C group, n=46). C group take Amlodipine Besylate Tablets only for 2months,while T group add Fangjihuangqi capsule. Serum NO and eNOS level was tested before and after this treatment. All results were analysed. Results Both groups have higher NO and eNOS level after treatment (р<0.01). Patient in T group show even higher NO and eNOS level than C group (р<0.05), and the degree of elevation was positively correlated with time of treatment. Conclusion Fangjihuangqi capsule shows great impact on serum NO and eNOS level in patients with hypertension , these could be one important mechanism by which it regulate blood pressure.