凯西莱联合丹参注射液治疗慢性乙型肝炎临床观察

Clinical efficacy of Tiopronin combined with Salviae miltiorrhiza injection in the treatment of Chronic Hepatitis B

目的:评价凯西莱联合丹参注射液治疗慢性乙型肝炎的疗效和安全性。方法:108例诊断为慢性乙型肝炎的患者随机分为治疗组和对照组,分别应用凯西莱联合丹参注射液和一般保肝治疗,观察患者一般情况、血常规、肝、肾功能、肝纤维化指标和治疗不良反应。结果:治疗组和对照组均能改善患者的症状和肝功能;治疗组的血清HA、PCⅢ、CⅣ、LN浓度显著下降。治疗组除个别患者出现皮疹外,未见其它不良反应。结论:凯西菜联合丹参注射液治疗慢性乙型肝炎有一定疗效,安全性好。

Objective To explore the efficacy and safety of in Tiopronin combined with salviae miltiorrhiza injection the treatment of chronic hepatitis B. Methods 108 Patients with chronic hepatitis B were randomly divided into two groups: the cure group (62patients)was given Tiopronin and salviae mihiorrhiza injection and the control group (46 patients)was given routine medicine,To observe the levels of serum fibrosis marks、blood normal regulations 、function of the liver and kidney and so on before and after treatment in two groups. Results The serum parameters of fibrosis all significantly (hyaluronic acid (HA)、type Ⅲ procollagen (PCⅢ)、laminin (LN)、type Ⅳ collagen (CⅣ)) changed after 1 months of treatment intreated groups,No side effects were observed except for very few rash. Conclusion Tiopronin combined with Salviae miltiorrhiza injection on chronic hepatitis B is more effective and saftey.