434株铜绿假单胞菌的耐药性分析

Antibiotic Resistance of 434 Strains of Pseudomonas aeruginosa

目的 研究铜绿假单胞菌对目前常用 38种抗菌药物的敏感性和耐药性 ,以利临床合理选用抗菌药物。方法 对我院 1998年 1月 1日～ 2 0 0 2年 2月 2 8日分离出 4 34株铜绿假单胞菌的药敏试验结果进行回顾分析。细菌菌落鉴定及药敏试验采用法国 Bio Merieux公司的 VITEK- 32全自动微生物分析仪。结果 4 34株铜绿假单胞菌对 38种常用抗菌药物的平均敏感率为 37.5 9% ,平均耐药率为 6 2 .4 1% ,3重以上耐药者占 78.5 7% ;4 34株铜绿假单胞菌感染患者 ,敏感率最高的是头孢哌酮 /舒巴坦为 87.5 0 % ,其他依次减少的是阿米卡星(86 .2 7% )、亚胺培南 (84 .6 9% )等。结论 铜绿假单胞菌是临床感染性疾病中常见致病菌之一 ,其耐药问题已十分突出 ;对于铜绿假单胞菌感染患者 ,经验性治疗可首选头孢哌酮 /舒巴坦、阿米卡星、亚胺培南等抗菌药物 ,β-内酰胺类 +氨基糖苷类为较优化的组合治疗方案 ,同时可联合使用大环内酯类抗菌药物以提高抗铜绿假单胞菌治疗效果。

OBJECTIVE To study the drug sensitivity and drug resistance of Pseudomonas aeruginosa to 38 commonly used antibiotics. METHODS To collect data of the 434 strains of bacteria separated from clinical specimen from Jan 1998 to Feb 2002 and make analyses on the drug sensitivity test. RESULTS The average drug sensitivity rate of P. aeruginosa to 38 commonly used antibiotics is 37.59%, average drug resistance rate is 62.41%. The drug resistant strains to more than triple drugs account for 78.57%. The sensitivity rate of cefoperazone/sulbactam is the highest (87.50%), the others in order are amikacin (86.27%) and imipenem(84.69%). CONCLUSIONS P. aeruginosa is one of the common pathogens in clinics. The problem of drug resistance is very prominent. With the patient infected by P. aeruginosa, it should be first treated experiencely by cefoperazone/sulbactam, amikacin and imipenem, et al.