摘要
目的优选妇舒宁颗粒乙醇提取的方法及制备工艺条件。方法采用正交试验法考察不同因素和水平对齐墩果酸和丹参酮ⅡA得率的影响,比较了乙醇渗漉法及回流法提取有效成分得率。结果回流法提取齐墩果酸和丹参酮ⅡA得率均高于渗漉法提取。影响回流法提取齐墩果酸、丹参酮ⅡA得率的主要因素是药材破碎度、乙醇浓度、加热回流次数和回流时间。结论最佳工艺条件为:药材均粉碎成最粗粉(过10目筛)、加90%乙醇回流3次,每次回流1h,乙醇用量首次为药材量的6倍,其余为5倍。
Objective To optimize the method and condition s for the extraction process of Fushuning Granules.Methods Different factors and levels were in vestigated by orthogonal design wit h yields of oleanolic acid and tanshi noneⅡ A as the markers.The yields of effective com ponents by percolation and reflux we re compared.Results The extraction ratio by re-flux was higher than that by percolation.The primary factors influencin g extraction ratio by reflux were the pulverization degree of medicinal materials,concentration of alcohol,refluxing times and refluxing perio d.Conclusion The opti-mum extraction process was:refluxing and extracting the pulverized med icinal materials for 3times(1hours each time )with 6-fold 90%alcohol added in the f irst time and then 5-fold in the secon d and the third time.
出处
《中药新药与临床药理》
CAS
CSCD
2003年第3期196-199,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广西壮族自治区卫生厅重点课题(编号200022)。
关键词
妇舒宁颗粒/化学
齐墩果酸/分析
丹参酮ⅡA/分析
正交试验
中药制剂工艺
Fushuning Granules /chemistry
Oleanolic acid /analysis
TanshinoneⅡ A /analysis
Orthogonal test
Pharmaceutical technology(TCD)