乌拉地尔治疗高血压危象的疗效与安全性分析

The therapeutic evaluation and adverse affects of urapidil in treatment of hypertensive crisis

目的 :与大剂量应用硝酸甘油比较观察乌拉地尔治疗高血压危象的临床疗效及其安全性。方法 :4 1例高血压危象患者随机分为A ,B两组 ;A组 1 9例为乌拉地尔治疗组 ,在同B组常规治疗的基础上予乌拉地尔治疗 ;B组 2 2例 ,为硝酸甘油治疗组 ,常规予吸氧、强心、利尿、硝酸甘油治疗。结果 :乌拉地尔和硝酸甘油在降低高收缩压上 ,乌拉地尔组较硝酸甘油组起效快 ,前 30min总有效率A组为 89 4 7% ,B组为 5 9 1 0 % (P <0 0 5 )。B组有血压下降过度及反射性心率加快的副作用。结论 :乌拉地尔治疗高血压危象起效快 ,效果显著 ,副作用少。可作为高血压危象患者首选治疗药物。

Objective:To compare the efficacy and side effects of urapidil and nitroglycerin in treatment of hypertensive crisis Methods:The study was conducted in 41 patients with hypertensive crisis In addition to receive the oxygen inhalation,cardiac diuretic and other regular therapy,they were randomly allocated to receive urapidil ( n =19,group A),or a large dose of nitroglycerin in intravenous perfusion ( n =22,group B) Results:BP was significantly reduced in group A in the early 30 minutes and no changes in heart rate were observed The total effective rate were 89 47% for urapidil group and 59 10% for nitroglycerin group with significant difference between groups But excessive descent of BP and reflex tachycardia were the side effects found in group B Conclusion:Urapidil is an effective and safe agent for treatment of hypertensive crisis