烧伤创面绿脓假单胞菌的分离及对哌拉西林/他唑巴坦耐药情况分析

Isolation of pseudomonas aeruginosa from burn wound and analysis of its resistance to Piperacillin/Tazobactam

目的 :探讨烧伤创面绿脓假单胞菌对哌拉西林 /他唑巴坦 (PIP/TAZ)的耐药性并与其他几种治疗绿脓假单胞菌感染的抗生素比较 ,寻找最佳的治疗用药。方法 :对烧伤创面分离出的 1 89株绿脓假单胞菌 ,用MI CROSCANAS 4细菌鉴定及药敏分析系统进行鉴定 ,用K B法进行药物敏感试验。结果 :几种常用于治疗绿脓假单胞菌的药物中 ,敏感性较高的依次为PIP/TAZ、哌拉西林、头孢他啶、氨曲南和泰能 ,其耐药率分别为 2 7 5 %、4 2 9%、 5 2 3%、 5 7 1 %、 74 6 %。结论

Objective: To investigate drug resistibility on piperacillin/tazobactam (PIP/TAZ) of Pseudomonas seruginosa from burn wounds,and to look for effective antibiotics for clinical therapy Methods: 189 P aeruginosa stratins isolated from burn wound were identified by MICROSCAN AS 4 system (automatic bacterial identification and drug sensitivity system). K B method was applied to the drug sensitive test Results: Of the several antibiotics which are used to cure the infection of P aeruginosa,the higher susceptibilities were: PIP/TAZ,Piperacillin,Ceftazidime,Aztreonam,and Imipenem The percentages of resistance were 27 5%?42 9%?52 3%?57 1%?74 6% respectively Conclusion: PIP/TAZ is one of the most ideal antibiotics to cure the infection of P aeruginosa on burn wound