摘要
目的 :观察中草药远志对小鼠雄性生殖细胞遗传物质损伤的保护作用。方法 :采用小鼠精原细胞姐妹染色单体互换实验。结果 :铅能诱发小鼠精原细胞姐妹染色单体互换 ,而在腹腔注射铅的同时给予远志 ,可使铅诱发的小鼠精原细胞姐妹染色单体互换频率明显降低。结论 :远志对雄性生殖细胞遗传物质具有保护作用 。
Objective:To observe the preventive effect of Polygala tenuifolia willd on genetic damage in genital cells of male mouse.Methods:The sister chromatid exchange (SCE) test in mouse spermatogonia was used. Results: Pb(CH 3COO) 2 could induce SCE in mouse spermatogonia,but the frequencies of SCE induced by Pb(CH 3COO) 2 in mouse spermatogonia were reduced significantly if Polygala tenuifolia willd and Pb(CH 3COO) 2 were given ip simultaneously.Conclusion:Polygala tenuifolia willd shows a protective effect,namely antimutagenesis,on genetic material in male genital cells.
出处
《吉林大学学报(医学版)》
CAS
CSCD
北大核心
2003年第3期258-260,共3页
Journal of Jilin University:Medicine Edition
基金
吉林省科研发展计划项目 (2 0 0 10 5 2 9)
关键词
远志/药理学
醋酸铅
精原细胞
姐妹染色单体交换/遗传学
抗诱变药/药理学
Polygala tenuifolia/pharmacology
Pb(CH 3COO) 2
Spermatogonia
Sister chromatidexchange/genetics
Antimutagenic agents/pharmacology