病毒性心肌炎患儿血清IL-4和IFN-γ含量变化的临床意义

Evaluation of Serum IL-4 and IFN-γ Level in Child Patients with Viral Myocarditis

目的 :探讨病毒性心肌炎患儿血清白细胞介素 - 4( IL- 4)和 γ干扰素 ( IFN- γ)含量变化及临床意义。方法 :采用双抗体夹心 ELISA方法检测 30例急性期和 1 5例迁延期患儿血清 IL- 4和IFN-γ含量 ,并分析二者的关系。结果 :急性期、迁延期患儿血清 IL- 4含量均低于正常对照组 ,IFN-γ含量高于正常对照组 ;急性期患儿血清 IL- 4和 IFN-γ呈显著负相关。结论 :病毒性心肌炎患儿血清 IL- 4含量降低 ,IFN-γ含量增高 ,体内 TH1应答强于 TH2 。

Objective: To explore the changes and clinical evaluation of serum IL 4 and IFN γ contents in child patients with viral myocarditis. Methods:Sandwich ELISA was used to detect IL 4 and IFN γ contents in the sera from 30 cases in acute attack and 15 cases in deferred stage,respectively. The results of detection and the relationship between IL 4 and IFN γ were analyzed statistically. Results:The serum IL 4 contents were lower than those of the normal control group and IFN γ contents were higher than those of the normal control group both in acute attack and in deferred stage. Linearregression showed that the serum IL 4 content was negatively correlated to the IFN γ content. Conclusion:The serum IL 4 content decreased and IFN γ content increased in child patients with viral myocarditis.