87株黄杆菌Ⅱb群的耐药特征分析

Investigation of drug-resistant characteristics of 87 strains of Flavobacterium Ⅱb group

目的 分析黄杆菌Ⅱb群对 2 0种抗生素的耐药特征。方法 采用WHO提供的临床实验室标准化委员会 (NCCLS)推荐的纸片琼脂扩散法 ,测定了 2年中初次分离的 87株黄杆菌Ⅱb群对环丙沙星等 2 0种抗生素的耐药特征 ,并对 4例黄杆菌Ⅱb群菌血症的治疗进行了分析。结果 黄杆菌Ⅱb群对阿米卡星、环丙沙星、氧氟沙星的敏感率最高 ,分别为 90 .5 %、79.8%、43 .3 % ,而对其它 1 7种抗生素 ,如氨苄青霉素等高水平耐药 ,敏感率为 0～ 6 % ,从阿米卡星、环丙沙星、氧氟沙星对黄杆菌Ⅱb群抑菌环直径分布累积百分率图看出 :阿米卡星、环丙沙星为活性最好的抗生素。结论 阿米卡星、环丙沙星对所分析的黄杆菌Ⅱb群有较高的活性 。

Objective To investigate the drug resistant characteristics of 87 strains of Flavobacterium Ⅱb group.Methods The disc diffusion method (NCCLS) was used to detect the zone diameter of 87 strains of Flavobacterium Ⅱb group against 20 antibiotics, which were isolated initially in the past two years. The therapeutic effect on 4 cases of bacteremia caused by Flavobacterium Ⅱb group was observed.Results Among 20 antibiotics,Amikacin (90.5%),Ciprofloxacin (79.8%) and Ofloxacin (43.3%) had higher susceptible rates. Flavobacterium Ⅱb group was highly resistant to the other 17 antibiotics and the susceptible rate was between 0 and 6%.The accumulative curve of zone diameter of 3 antibiotics showed that amikacin and ciprofloxacin were the most effective antimicrobial agents.Conclusion Amikacin and ciprofloxacin are the most active antibiotics against Flavobacterium Ⅱb group and they are also the most ideal antimicrobial agents for treating the bacteremia caused by Flavobacterium Ⅱb group.