纳络酮治疗急性大面积脑梗死的近期疗效观察

The therapeutic effect of naloxone on treating acute cerebral infarction of large area

目的 通过对照开放性临床研究 ,在早期有效的脱水治疗基础上 ,对早期应用大剂量纳络酮治疗急性大面积脑梗死的有效性及安全性进行评价。方法 将 91例急性大面积脑梗死病人按 2∶1随机分为试验组和对照组 ,2组均早期应用甘露醇脱水治疗 ,待脑水肿消退后改用血液稀释治疗。试验组入院时即加用纳络酮 4 .8mg d ,分 2次静滴 ,共 1 4d。结果 试验组治疗后 1 4d神经功能缺损恢复程度明显优于对照组 ,显效率 36 .0 7% ,总有效率 86 .89% ,有非常显著性差异 (P <0 .0 0 1 )。进一步观察 ,纳络酮在 72h内应用 ,各时间段疗效有明显差异 (P <0 .0 0 1 ) ,从发病到治疗时间越短神经功能恢复越快。

Objective To investigate the clinical effect and safety of naloxone in treating patients with acute cerebral infarction of large area. Methods 91 patients with acute cerebral infarction of large area were randomly divided into two groups, treatment group (n=61) and control group (n=30). All the patients were treated with 20% mannitol in early stage, while the patients in treatment group were given naloxone in addition,2.4 mg once, twice a day, for 14 days. Results The recovery degree of nervous function in treatment group was much better than that of control group (P<0.001). The effective rate and total effective rate in treatment group was 36.07% and 86.89 % respectively, compared with those of control group, there was a significant difference between two groups (P<0.001). Conclusion Naloxone is an effective and safe drug for treating patients with acute cerebral infarction of large area.