不同硒化合物在WISTAR大鼠主要组织器官中的分布

SELENIUM DISTRIBUTION IN ORGANS OF RAT FOLLOWING AN ORAL ADMINISTRATION OF VARIOUS SELENIUM COMPOUNDS

对Wistar大鼠一次性灌服亚硒酸钠、硒代硫酸软骨素、硒代蛋氨酸和硒酵母后,硒在小肠、肝脏、肾脏和心脏中的含量均有提高,不同硒化合物在不同脏器中的时效规律不完全相同,但主要脏器的硒排出过程均符合指数扩散规律.硒代蛋氨酸在脑中积累,在其他脏器中表现明显滞留效应.脏器硒含量顺序为硒代蛋氨酸>亚硒酸钠≈硒代硫酸软骨素>硒酵母.

Raised selenium levels in blood, intestine, liver, kidney, heart, and brain of rat were observed following an oral administration of selenite, seleno-chon-doitine sulfate, selenomethionine, or seleno-yeast. Selenium contents in these organs decreased exponentially and behaved differently among the compounds tested. Seleno-methionine showed to be accumulated in the brain and to be more detained in other organs when compared with selenite and seleno-chondoi-tine sulfate. The maximum level of selenium in different organs obtained by administering selenium compounds decreased follows an order of seleno-methio-nine > selenite≈seleno-chondoitine sulfate > seleno-yeast.