摘要
The regulating effects of TCM treatments including clearing away heat and toxic materials ,promoting blood circulation and removing blood stasis,and strengthening the spleen and regulating qi on the oncogene transcription were observed in the liver cancer model rats.The preliminary results indicated that the mRNA levels of H-ras N-ras and K-ras,and signal moleculs correlated with the ras/MAPK signal transduction pathway were down-regulatedf by the differnet TCM treatment in varying degrees.Also,the regulating effects of the treatment on differently-displayed genes were discrepant.It is suggested that the molecular mechanisms of the TCM treatments for liver cancer was complex with different target genes.
The regulating effects of TCM treatments including clearing away heat and toxic materials,promoting blood circulation and removing blood stasis,and strengthening the spleen and regulating qi on the oncogene transcription were observed in the liver cancer model rats.The preliminary results indicated that the mRNA levels of H-ras N-ras and K-ras,and signal molecules correlated with the ras/MAPK signal transduction pathway were down-regulated by the different TCM treatments in varying degrees.Also,the regulating effects of the treatments on differently-displayed genes were discrepant.It is suggested that the molecular mechanisms of the TCM treatments for liver cancer was complex with different target genes.
关键词
大鼠
肝癌
相关基因转录
中医药疗法
调节作用
Animals
Diethylnitrosamine
Drugs, Chinese Herbal
Genes, ras
Liver Neoplasms, Experimental
Male
Mitogen-Activated Protein Kinase Kinases
Protein-Serine-Threonine Kinases
RNA, Messenger
Rats
Rats, Wistar
Signal Transduction
Transcription, Genetic
ras Proteins
