间断低氧大鼠谷胱甘肽过氧化物酶及还原型谷胱甘肽的变化

The Changes of Glutathione Peroxidase and Reduced Glutathione in Intermittently Hypoxic Rats

动态测定了常压间断低氧大鼠全血和肺组织谷胱甘肽过氧化物酶(GSH-PX)活性及还原型谷胱甘肽(GSH)含量。结果发现随低氧时间延长,肺动脉压逐渐升高的过程中有全血及肺组织GSH-PX活性及GSH含量的显著降低。维生素E和山莨菪碱有部分保护作用。提示间断低氧过程中活性氧自由基生成增多,消耗了较多的抗氧化酶(剂)。氧自由基生成增多可能在其肺动脉高压的发生中起一定作用。

Glutathione peroxidase (GSH-PX) activities and redused glutathione (GSH) contents of blood and lung parenchyma were measured during intermittent exposure to hypoxia in rats. It was found that GSH-PX activities and GSH contents were significantly decreased with increase of pulmonary arterial pressure caused by hypoxia. Vit E and Anisodamine have some alleviatory effect on above changes. The results suggestad that in the process of intermittently hypo-xic pulmonary hypertension in rats, generation of oxygen free radicals in lung tissue increased, which may play a role in pathogenesis of pulmonary hypertension.