犬出血性胰腺炎门静脉血液流变学与血清发光变化

Changes of Haemorheology and Free Radicals in Portal Venous Blood During Hemorrhagic Pancreatitis in Dog

经犬主胰管逆行加压注射犬自体胆汁(0.5ml/kg)制成AHP动物模型;AHP第2小时,门静脉全血高切粘度、全血低切粘度、红细胞压积与红细胞聚集性增加,血清自发光强度增加;AHP第6小时,血液流变学紊乱的上述参数逐渐加重,血清自发光强度与脂质过氧化物均增加。同时,全血高切粘度、全血低切粘度、红细胞压积与红细胞聚集指数与血清自发光强度在AHP时相互关系明显。结果表明:高血粘与自由基反应在AHP发展过程中起一定的作用,二者相互影响。

Acute hemorrhagic pancreatitis (AHP) was produced by retrograde forced injection of antogenous bile (0.5ml/kg) into the main pancreatic duct. Whole blood viscosity (WBV) at 230S-1,WBV at 5.75S-1 haematocrit (Ht) , erythrocyte aggregation index (EAI) and intensity of serum chemiluminance were increased at second hour of AHP. The above indexes of haemorheology disorder were aggravated. Intensity of serum chemiluminance and lipid peroxidation were increased. There was relevance of WBV at 230S-1,WBV at 5.75S-1,Ht, EAI with intensity of serum chemilunance. The results may review that hyperviscosity and action of radicals has some effect on pathological evolvement of AHP and were influenced each other.