类风湿因子分型(IgG、IgM、IgA)与丙型肝炎关系的初探

The discussion about the relation between RF(lgG、lgM、lgA)type and anti-HCV

为了了解类风湿因子 (RF)自身免疫抗体的分型 (IgG、IgM、IgA)与丙型肝炎之间的关系 ,探讨其出现的规律及与肝功能损坏情况的相关性。采用定量双抗原夹心ELISA法进行检测。结果发现抗 HCV阴性、ALT <4 0U的C组RF总阳性率为 5 % ;抗 HCV阳性、ALT <4 0U的A组为 5 6 % :抗 HCV阳性 ,ALT≥ 4 0U的B组为 89% ,C组与A、B组之间有显著性的差异P <0 .0 1)。A组lgM RF阳性率为 4 % ;B组为 5 6 % ;A组与B组之间有显著性差异 (P <0 .0 5 )。因此抗 HCV阳性者血清中各型RF总阳性率比正常对照的C组有明显的增高 ;B组的IgM RF比A组明显地增高。研究结果提示 :IgM

To observe the relation between RF type and anti HCV positive,and further find the relativity between its present and liver damage degree,the quantity double antigen sandwich ELISA was used.The results suggest that the positive rate of RF is 5%in the negative anti HCV group(C),61%in the positive anti HCV and ALT 1ess than 40U group(A),89%in the positive anti HCV and ALT more than 40U group(B),the group C has significant difference to the group A and B( P <0.01),the positive rate of IgM RF i s 9%in group A,56%in the group B,the significant difference is between the group A and B( p <0.05). So we can make a conclusion that the total positive rate of RF in patients with positive anti HCV significantly increased to the control,the significant difference is between the IgM RF group with positive anti HCV and ALT more than 40U and that with ALT 1ess than 40U,it suggested that the increase of IgM RF had close relation to the liver damage patients with HCV.