软珊瑚Sarcophyton crassocaule中Cembrane型二萜的分离与鉴定

Isolation and Identification of a Novel Cembrane-type Diterpenoid from the Soft Coral Sarcophyton crassocaule

从采自中国南海西沙群岛海域的软珊瑚 Sarcophyton crassocaule中分离得到一种结构新颖的Cembrane型二萜 ,经 1 H NMR,1 3 C NMR,HMQC,1 H-1 HCOSY,NOESY,FABMS和 X射线晶体衍射确定其结构 ,命名为 Sarcocrassolide B它对 P388的细胞毒性为 1 .5 μg/m L.

A novel cembrane-type diterpenoid was first isolated from the soft coral Sarcophyton crassocaule collected from the Xisha Islands in the South China Sea. Its structure was determined on 2D-NMR, HRMASS and IR techniques and the relative configuration was confirmed by NOESY and X-ray diffraction. The crystal is monoclinic, space group P2 1 with cell dimensions of a=0.890 00(10) nm, b=0.638 0(10) nm, c=1.169 670(2) nm. α=90°, β=92.470(10)°, γ=90°, V=0.926(3) nm 3, D=1.192 4 g/cm 3, Z=2, R=0.057 8, wR=0.138 0. The new compound was named as Sarcocrassolide B. It exhibited a strong cytotoxicity against P388 cell line with IC 50 value of 1.5 μg/mL.