广西七城市围产儿先天畸形危险因素的病例对照研究

A case-control study on the risk factor of perinatals' congenital malformations in seven cities of Guangxi

目的 探讨广西城区围产儿先天畸形的危险因素。方法 随机抽取 2 0 0 0年在广西七城市所属 6 2所医院 (不包括郊区、县医院 )出生的 2 81例畸形儿和 730名对照进行病例对照研究和单因素、多因素非条件logistic回归分析。 结果 先天畸形的主要危险因素是 :多产次 (OR =2 .6 ) ,有妊娠合并症 (OR =3.2 ) ,母亲妊娠前后接触化学制剂 (OR =3.0 ) ,孕期服用镇静药 (OR =10 .2 )、激素类药物 (OR =9.4)、中成药 (OR =2 .5 ) ,母亲血型为AB型 (OR =3 .5 )、A型 (OR =2 .2 ) ,母亲孕期情绪紧张、忧郁 (OR =2 .6 ) ,母亲职业为工人 (OR =3.8)、农民 (OR =3 .0 ) ,父亲接触噪声 (OR =5 .7)、有慢性病 (OR =2 .8)。结论 母亲孕期服镇静药、激素类药、中成药 ,情绪紧张、忧郁 ,多产次 ,有妊娠合并症 ,母亲妊娠前后接触化学制剂 ,母亲血型为AB型、A型 ,职业为工人、农民 ,父亲接触噪声、有慢性病等是围产儿先天畸形的危险因素。

Objective To investigate the possible risk factors of congenital malformations in cities of Guangxi. Methods A case-control study was carried out on 281 cases of congenital malformations and 730 controls. Analysis of simple factor and multiple factors unconditional logistic regression were done. Results The analysis of simple factor and multiple factors showed that main risk factors of congenital malformations as multiple pregnancies ( OR = 2.6), pregnancy complications ( OR = 3.2), exposure to chemical substances before or during pregnancy ( OR = 3.0), taking sedatives ( OR = 10.2), hormone drug ( OR = 9.4) or Chinese herbal medicines ( OR = 2.5) during the early stage of pregnancy, mothers' blood type as AB ( OR = 3.5) or A ( OR = 2.2), mothers' emotion being nervous and melancholy ( OR = 2.6), mothers' occupation being workers ( OR = 3.8) or peasants ( OR = 3.0), fathers' exposure to noise ( OR = 5.7) or suffering from chronic diseases ( OR = 2.8). Conclusions Some risk factors were identified as having important effect on perinatal congenital malformations, including taking sedatives, hormone drug or Chinese herbal medicines during the early stage of pregnancy, mothers' emotion being nervous and melancholy,multiple pregnancies, pregnancy complications, exposure to chemical substances before or during pregnancies,mothers' blood type as AB or A, mothers' occupation being workers or peasants, fathers' exposure to noise or suffering from chronic diseases. [